Research Stream 1 – Metabolism and sleep

Aim: Reduce the cardio-metabolic impact of poor sleep

Shortened, disrupted and desynchronised sleep (as occurs in shiftworkers) is associated with metabolic abnormalities and increased mortality. Obstructive Sleep Apnea (OSA) has also been shown as an independent risk factor for mortality. In addition, obesity, metabolic syndrome, insulin resistance, diabetes mellitus, stroke, coronary artery disease, hypertension and erectile dysfunction are common in OSA and contribute to mortality, morbidity and reduced productivity in people with sleep apnea. Therefore when treating OSA it may be important to clinically "co-manage" other associated conditions. Knowledge of how sleep apnea impacts on some metabolic conditions and vice versa may be important considerations.

Projects within this stream of CIRUS research which are planned or currently running include:

  1. Long term follow up of population groups to examine the link between metabolic problems and sleep health
  2. Exploring the effect of various hormones on sleep; developing possible hormone predictors for sleep disorders
  3. Timing therapy for optimal control of sleep interdependent conditions such as blood pressure
  4. Examining the role of puberty on aspects of health such as sleep disorders, asthma, snoring and cardiovascular risk